Evidence-Based
by Design
Every sensor channel, every ML feature, and every clinical claim is grounded in peer-reviewed literature. Here is the research that underpins NeuroPatch.
Supporting Literature
Key peer-reviewed papers informing the NeuroPatch sensor selection and ML architecture.
Key Findings
Aggregate evidence from the research literature supporting the physiological biomarker approach to bipolar disorder monitoring.
- Sweat-based cortisol electrochemical sensing correlates with serum cortisol during psychological stress, supporting its use as a continuous HPA axis proxy in wearable form factors
- Combined EDA and EMG co-elevation is associated with manic prodrome onset in published bipolar physiological monitoring studies
- Multimodal sensor fusion consistently outperforms single-channel approaches for affect state classification across published wearable datasets
- EDA measurements from body-worn sensors show reliable sympathetic arousal tracking at clinically relevant timescales during naturalistic daily activity
- BiLSTM architectures trained on individual patient baselines reduce false positive rates compared to population-level threshold approaches
Join Our Research Network
We are actively seeking psychiatric research institutions, academic medical centers, and clinical investigators interested in physiological monitoring for bipolar disorder. Collaborations for protocol development and multi-site study participation welcome.
Get In TouchMulti-site clinical study currently in planning phase. IRB protocol under preparation. Target participant population: adults with confirmed DSM-5 bipolar I or II diagnosis, currently under psychiatric care.
Research Timeline
Our structured path from sensor validation to regulatory submission.
Sensor Validation
Validating signal quality, electrode placement, and clinical-grade SNR across all five sensor channels on the NeuroPatch prototype.
BiLSTM Development
Developing and tuning the BiLSTM mood episode detection model using WESAD and published physiological datasets.
Feasibility Study
Feasibility study protocol in development for bipolar I and II participants. Collaborating psychiatric institution identified. IRB engagement in progress.
Multi-Site Study
Multi-site clinical study across two psychiatric institutions following feasibility study completion. Protocol and IRB submission planned.
Regulatory Submission
Type II medical device classification submission following completion of clinical studies and compilation of safety and efficacy data.